There are tons of threads on this but I can't seem to find any about the same issue I'm having. I set up my Reference Line and added an angle parameter and that works perfectly. The problem occurs when I nest my Generic Annotation Handicap symbol in and try to align and lock it to the angled Reference Line. As soon as I flex the angle parameter I get an error message that Constraints are not satisfied and the wheelchair symbol is unconstrainted. Anyone have any tips on nesting?