This one is pretty basic but it surprised me because I didn't notice it until now, after 5 years of using CAD.
It is a real time saver when plotting multiple parts of the same drawing more than once:
In the upper right corner of the Page Setup or Plot dialog box there is a "Page setup name" tab where you can select one of a number of named plotting configurations. To create a new one, simply click on the Add button and continue as normal setting up your page or plot job.
Your new setup will be automatically saved and will be available from now on every time you open the drawing.